Gingival Tissue Transcriptomes Identify Distinct Periodontitis Phenotypes
نویسندگان
چکیده
منابع مشابه
Prostaglandin E synthases in periodontitis-affected gingival tissue and in gingival fibroblasts
Periodontitis is a chronic inflammatory disease resulting in the destruction of the tissue and alveolar bone supporting the teeth and leading ultimately to tooth loss. Prostaglandin E2 (PGE2) is an important inflammatory mediator in the pathogenesis of periodontitis. The biosynthesis of PGE2 is catalysed by three groups of enzymes acting sequentially: phospholipase A2 (PLA2), cyclooxygenases (C...
متن کاملTranscriptomes in healthy and diseased gingival tissues.
BACKGROUND Clinical and radiographic measures are gold standards for diagnosing periodontitis but offer little information regarding the pathogenesis of the disease. We hypothesized that a comparison of gene expression signatures between healthy and diseased gingival tissues would provide novel insights in the pathobiology of periodontitis and would inform the design of future studies. METHOD...
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BACKGROUND AND AIM: Until now there are a few case reports in which idiopathic gingival enlargement and aggressive periodontitis are diagnosed in combination but in none of them unilateral aggressive periodontitis was seen. CASE REPORT: A 25-year-old female was referred with the chief complaint of swelling of the gingiva in the regions of right upper and lower jaws, for the past 7 years. No rel...
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A new species of torque teno mini virus, named TTMV-222, was detected in gingival tissue from periodontitis patients using a viral metagenomics method. The 2803-nucleotide genome of TTMV-222 is closely related to TTMV1-CBD279, with 62.6% overall nucleotide similarity. Genetic analyses of the new virus genome revealed a classic genomic organization but a weak identity with known sequences. The p...
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Periodontitis are infections that may cause systemic consequences. Due to that it is important to make an accurate histopathologic diagnosis as soon as possible. The aim of this study was to determine the main changes from the gingival mucosa biopsy taken from generalized chronic periodontitis (GCP) patients by light microscopy (LM) and transmission electron microscopy (TEM). The results were c...
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ژورنال
عنوان ژورنال: Journal of Dental Research
سال: 2014
ISSN: 0022-0345,1544-0591
DOI: 10.1177/0022034514527288